Benefits Mechanism of action Trazodone is a serotonin reuptake inhibitor and is also a 5-HT2 receptor antagonist.
However, in contrast to the SSRIs, trazodone's antidepressant effects may be due to its antagonistic action at the 5-HT2 receptor site.
The diagnosis of RLS is based on a patient’s symptoms and answers to questions concerning family history of similar symptoms, medication use, the presence of other symptoms or medical conditions, or problems with daytime sleepiness. In people with mild to moderate restless legs syndrome, lifestyle changes, such as beginning a regular exercise program, establishing regular sleep patterns, and eliminating or decreasing the use of caffeine, alcohol, and tobacco, may be helpful.
Treatment of an RLS-associated condition also may provide relief of symptoms.
Currently, trazodone is the second most commonly prescribed treatment for insomnia.
However its advantage is that unlike most sleeping pills, it is not addictive and not habit forming.
Trazodone: "off-label" sleeping pill Trazodone hcl is a sedating antidepressant with significant anxiolytic and sedative activity.
In practice it is widely used off-label to treat insomnia.
The sensations are usually worse at rest, especially when lying or sitting.
The severity of RLS symptoms ranges from mild to intolerable.